BackgroundDelusional thinking is one SUPER ENZYMES of the hallmark symptoms of schizophrenia.However, the underlying neural substrate for delusions in schizophrenia remains unknown.In an attempt to further our understanding of the neural basis of delusions, we explored gray matter deficits and their clinical associations in first-episode schizophre
Comparison of Cartridge-Based Nucleic Acid Amplification Test with Fine Needle Aspiration Findings in Suspected Tubercular Lymphadenitis
Lymphadenopathy is a common but non-specific presentation of tuberculosis.Fine Needle Aspiration Cytology (FNAC) and Ziehl Neelsen (ZN) stain are preferred investigations of choice in evaluating lymphadenopathy.The aspirate obtained from FNAC may be used to perform a cartridge-based nucleic acid amplification test (CBNAAT).This study aimed to asses
Transcriptomic insights into the roles of the transcription factors Clr1, Clr2 and Clr4 in lignocellulose degradation of the thermophilic fungal platform Thermothelomyces thermophilus
Introduction:Thermothelomyces thermophilus, formerly known as Myceliophthora thermophila, is used in industry to produce lignocellulolytic enzymes and heterologous proteins.However, the transcriptional network driving the expression of these proteins remains elusive.As a first step to systematically uncover this network, we investigated growth, pro
Investigations of the Windage Losses of a High-Speed Shrouded Gear via the Lattice Boltzmann Method
To suppress the adverse effect of the gear windage phenomenon in the high-speed aeronautic industry, a shroud as an effective alternative strategy is usually Condoms to enclose gears to reduce the windage behaviors of high-speed gears.To deeply understand these no-load power losses, this paper proposes a new simulation methodology based on the Latt
Metformin Enhances Antidepressant/Antipsychotic Combination Therapy of Schizophrenia With Comorbid Depression in a Murine Model
Comorbid depressive disorders confound the diagnosis and therapy of schizophrenia.Using a murine model incorporating both MK801 and chronic unpredictable mild stress exposures, we successfully replicated both psychosis and depression.Ex vivo patch clamp recordings and in vivo calcium imaging demonstrated impaired neural activity in the prefrontal C