Comparison of Cartridge-Based Nucleic Acid Amplification Test with Fine Needle Aspiration Findings in Suspected Tubercular Lymphadenitis

Lymphadenopathy is a common but non-specific presentation of tuberculosis.Fine Needle Aspiration Cytology (FNAC) and Ziehl Neelsen (ZN) stain are preferred investigations of choice in evaluating lymphadenopathy.The aspirate obtained from FNAC may be used to perform a cartridge-based nucleic acid amplification test (CBNAAT).This study aimed to asses

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Transcriptomic insights into the roles of the transcription factors Clr1, Clr2 and Clr4 in lignocellulose degradation of the thermophilic fungal platform Thermothelomyces thermophilus

Introduction:Thermothelomyces thermophilus, formerly known as Myceliophthora thermophila, is used in industry to produce lignocellulolytic enzymes and heterologous proteins.However, the transcriptional network driving the expression of these proteins remains elusive.As a first step to systematically uncover this network, we investigated growth, pro

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Metformin Enhances Antidepressant/Antipsychotic Combination Therapy of Schizophrenia With Comorbid Depression in a Murine Model

Comorbid depressive disorders confound the diagnosis and therapy of schizophrenia.Using a murine model incorporating both MK801 and chronic unpredictable mild stress exposures, we successfully replicated both psychosis and depression.Ex vivo patch clamp recordings and in vivo calcium imaging demonstrated impaired neural activity in the prefrontal C

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